Recurrent ocular toxoplasmosis is associated with interferon-gamma deficiency possibly due to genetic origin.

ABSTRACT:

Objective

Ocular toxoplasmosis (OT) can cause posterior uveitis; causes of recurrent OT are not well understood. We explored clinical, immunological and genetic properties associated with recurrent OT.

Methods and analysis

A recurrent OT patient population (n=9) was identified. Clinical history, ophthalmological findings and immunological properties were assessed. B and T cell immunophenotyping including interferon-gamma (IFN-γ) responses were analysed. An analysis of 592 immunodeficiency genes was performed.

Results

The patients experienced 2-7 OT episodes (average 3.7). The first episode occurred at an average of 23.8 (SD 10.1) years of age. All patients had anterior uveitis, vitritis and various fundus lesions of OT. The patients had lymphocyte maturation abnormali

SUBMITTER: Hautala NM 

PROVIDER: S-EPMC11404243 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature