Building and validating trend-based multiple sclerosis case definitions: a population-based cohort study for Manitoba, Canada.

ABSTRACT:

Objective

This study aims to (1) build and validate model-based case definitions for multiple sclerosis (MS) that use trends (ie, trend-based case definitions) and (2) to apply dynamic classification to identify the average number of data years needed for classification (ie, average trend needed).

Design

Retrospective cohort study design.

Participants

608 MS cases and 59 620 MS non-cases.

Setting

Data from 1 April 2004 to 31 March 2022 were obtained from the Manitoba Population Research Data Repository. MS case status was ascertained from homecare records and linked to health data. Trend-based case definitions were constructed using multivariate generalised linear mixed models applied to annual numbers of general and specialist physician visits, hospitalisation

SUBMITTER: Hamm NC 

PROVIDER: S-EPMC11404245 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature