Serum amyloid A for predicting prognosis in patients with newly diagnosed Crohn's disease.

ABSTRACT:

Objective

Serum amyloid A (SAA) was found to be positively correlated with the activity of Crohn's disease (CD); however, its prognostic value remains uncertain. Here, we examined its predictive ability in newly diagnosed CD and explored genetic association.

Methods

This retrospective cohort study included patients newly diagnosed as CD at the First Affiliated Hospital of Sun Yat-sen University between June 2010 and March 2022. We employed receiver operating characteristic curve, Cox proportional hazard regression models and restricted cubic splines to investigate the prognostic performance of SAA for surgery and disease progression. To assess possible causality, a two-sample Mendelian randomisation (MR) of published genome-wide association study data was conducted.

Resul

SUBMITTER: Chen Q 

PROVIDER: S-EPMC11404264 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature