Systematic review and meta-analysis of biomarkers predicting decompensation in patients with compensated cirrhosis.

ABSTRACT:

Background and aims

The transition from compensated to decompensated cirrhosis is crucial, drastically reducing prognosis from a median survival of over 10 years to 2 years. There is currently an unmet need to accurately predict decompensation. We systematically reviewed and meta-analysed data regarding biomarker use to predict decompensation in individuals with compensated cirrhosis.

Methods

PubMed and EMBASE database searches were conducted for all studies from inception until February 2024. The study was carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Quality of Prognosis Studies framework was used to assess the risk of bias. The meta-analysis was conducted with a random effects model using STATA software.

Res

SUBMITTER: Gananandan K 

PROVIDER: S-EPMC11404266 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature