Exposure to DDT and DDE and functional neuroimaging in adolescents from the CHAMACOS cohort.

ABSTRACT:

Background

Epidemiological studies suggest that exposure to p,p'-dichloro-diphenyl-trichloroethane (p,p'-DDT) is associated with poorer cognitive function in children and adolescents, but the neural mechanisms underlying this association remain unclear.

Objective

We investigated associations of prenatal and childhood exposure to p,p'-DDT and its metabolite p,p'-dichloro-diphenyl-dichloroethylene (p,p'-DDE) with cortical activation in adolescents using functional near-infrared spectroscopy (fNIRS).

Methods

We administered fNIRS to 95 adolescents from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) aged 15-17 years. We assessed cortical activity in the frontal, temporal, and parietal brain regions while participants completed tasks of

SUBMITTER: Binter AC 

PROVIDER: S-EPMC11404404 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature