Preparation of transferrin-targeted temozolomide nano-micelles and their anti-glioma effect.

ABSTRACT:

Objectives

This study aims to develop brain-targeted temozolomide (TMZ) nanograins using the biodegradable polymer material PEG-PLA as a carrier. The model drug TMZ was encapsulated within the polymer using targeted nanotechnology. Key characteristics such as appearance, particle size, size distribution, drug loading capacity, in vitro release rate, stability, and anti-tumor effects were systematically evaluated through in vitro experiments.

Methods

Transmission electron microscopy (TEM) and Malvern size analyzer were employed to observe the morphological and particle size features of the TMZ nanospheres at various time points to assess stability. The effects of TMZ nanograins on glioma cell viability and apoptosis were evaluated using MTT assays and flow cytom

SUBMITTER: Yu J 

PROVIDER: S-EPMC11404485 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature