The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

ABSTRACT: The hypoxia inducible factor (HIF) plays an important role in the progression of a number of pathophysiological processes including tumorigenesis. In addition to several well characterized oxygen-dependent modes of regulation, the function of the HIF transcription factor can also be influenced through the action of other regulatory pathways. Misregulation of these factors resulting in inappropriate HIF expression or activity can contribute to the progression of human cancers through the induction of genes promoting angiogenesis, glycolysis, cell survival, and metastasis, among other processes. The candidate tumor suppressor protein inhibitor of growth family member 4 (ING4) has recently been implicated as a repressor of angiogenesis and tumor growth through association with NF-kappaB. Here

SUBMITTER: Ozer A 

PROVIDER: S-EPMC1140452 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature