CircBIRC6 affects prostate cancer progression by regulating miR-574-5p and DNAJB1.

ABSTRACT:

Background

Prostate cancer (PCa) is among the three main types of cancer. Although prostate-specific antigen (PSA) is routinely tested, it has disadvantages, such as poor prognostic ability. Therefore, finding more PCa markers and therapeutic targets remains a subject of study. CircRNAs have been found to have regulatory roles in various diseases, such as diabetes, Central Nervous System (CNS) neuropathy, etc. where their application in cancer is even more valuable. Therefore, this paper aims to search for differentially expressed circRNAs in PCa and find downstream targeting pathways related to autophagy.

Method

By detecting the expression of circRNA in the samples, hsa_circ_0119816 was finally identified as the research target. The properties of circRNA were verified by RN

SUBMITTER: Zhao B 

PROVIDER: S-EPMC11404571 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature