Establishing Criteria for Tumor Necrosis as Prognostic Indicator in Colorectal Cancer.

ABSTRACT: Tumor necrosis has been reported to represent an independent prognostic factor in colorectal cancer, but its evaluation methods have not been described in sufficient detail to introduce tumor necrosis evaluation into clinical use. To study the potential of tumor necrosis as a prognostic indicator in colorectal cancer, criteria for 3 methods for its evaluation were defined: the average percentage method (tumor necrosis percentage of the whole tumor), the hotspot method (tumor necrosis percentage in a single hotspot), and the linear method (the diameter of the single largest necrotic focus). Cox regression models were used to calculate cancer-specific mortality hazard ratios (HRs) for tumor necrosis categories in 2 colorectal cancer cohorts with more than 1800 cases. For reproducibility asse

SUBMITTER: Kastinen M 

PROVIDER: S-EPMC11404753 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature