Development of a transgenic mouse model susceptible to human coronavirus 229E.
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ABSTRACT:
SUBMITTER: Lassnig C
PROVIDER: S-EPMC1140478 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Publications
Development of a transgenic mouse model susceptible to human coronavirus 229E.
Lassnig Caroline C Sanchez Carlos M CM Egerbacher Monika M Walter Ingrid I Majer Susanne S Kolbe Thomas T Pallares Pilar P Enjuanes Luis L Müller Mathias M
Proceedings of the National Academy of Sciences of the United States of America 20050526 23
Human coronavirus (HCoV) 229E is a group 1 coronavirus and is specific to humans. So far, no animal model is available to study the pathogenesis of infection by HCoV-229E. We show here that the expression of aminopeptidase N (APN, also termed CD13), the receptor for HCoV-229E, is required but not sufficient to confer susceptibility in vivo. HCoV-229E infection was facilitated by crossing APN transgenic mice into signal transducers and activators of transcription (Stat) 1 null mice and by adaptat ...[more]
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