Causal influence of plasma metabolites on age-related macular degeneration: A Mendelian randomization study.

ABSTRACT: Using genome-wide association study data from European populations, this research clarifies the causal relationship between plasma metabolites and age-related macular degeneration (AMD) and employs Metabo Analyst 5.0 for enrichment analysis to investigate their metabolic pathways. Employing Mendelian randomization analysis, this study leveraged single nucleotide polymorphisms significantly associated with plasma metabolites as instrumental variables. This approach established a causal link between metabolites and AMD. Analytical methods such as inverse-variance weighted, Mendelian randomization-Egger, and weighted median were applied to validate causality. Mendelian Randomization Pleiotropy Residual Sum and Outlier was utilized for outlier detection and correction, and Cochran's Q test was

SUBMITTER: Wang T 

PROVIDER: S-EPMC11404906 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature