PANoptosis-related molecular clustering and prognostic signature associated with the immune landscape and therapy response in breast cancer.

ABSTRACT: Breast cancer (BC) remains one of the most pervasive and complex malignancies. PANoptosis represents a recently identified cellular mechanism leading to programmed cell death. However, the prognostic implications and influence on the immune microenvironment of BC pertaining to PANoptosis-related genes (PRGs) remain significantly understudied. We conducted differential expression analysis to identify prognostic-Related PRGs by the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Next, we identified the PANoptosis-related molecular subtype using the consensus clustering analysis, and constructed and validated the PANoptosis-related prognostic signature using LASSO and Cox regression analyses. ROC curves were employed to assess the performance of the signatures. Fur

SUBMITTER: Cao Y 

PROVIDER: S-EPMC11404910 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature