Strain- and sex-specific differences in intestinal microhemodynamics and gut microbiota composition.

ABSTRACT:

Background

Intestinal microcirculation is a critical interface for nutrient exchange and energy transfer, and is essential for maintaining physiological integrity. Our study aimed to elucidate the relationships among intestinal microhemodynamics, genetic background, sex, and microbial composition.

Methods

To dissect the microhemodynamic landscape of the BALB/c, C57BL/6J, and KM mouse strains, laser Doppler flowmetry paired with wavelet transform analysis was utilized to determine the amplitude of characteristic oscillatory patterns. Microbial consortia were profiled using 16S rRNA gene sequencing. To augment our investigation, a broad-spectrum antibiotic regimen was administered to these strains to evaluate the impact of gut microbiota depletion on intestinal microhemodynami

SUBMITTER: Fu S 

PROVIDER: S-EPMC11405090 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature