3D printed O₂-generating scaffolds enhance osteoprogenitor- and type H vessel recruitment during bone healing.

ABSTRACT: Oxygen (O₂)-delivering tissue substitutes have shown tremendous potential for enhancing tissue regeneration, maturation, and healing. As O₂ is both a metabolite and powerful signaling molecule, providing controlled delivery is crucial for optimizing its beneficial effects in the treatment of critical-sized injuries. Here, we report the design and fabrication of 3D-printed, biodegradable, O₂-generating bone scaffold comprising calcium peroxide (CPO) that once hydrolytically activated, provides long-term generation of oxygen at a controlled, concentration-dependent manner, and polycaprolactone (PCL), a hydrophobic polymer that regulate the interaction of CPO with water, preventing burst release of O₂ at early time points. When anoxic conditions wer

SUBMITTER: Sarkar N 

PROVIDER: S-EPMC11405102 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature