Blood-based biomarkers of neuronal and glial injury in active major neuropsychiatric systemic lupus erythematosus.

ABSTRACT:

Background

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a poorly understood and heterogeneous manifestation of SLE. Common major NPSLE syndromes include strokes, seizures, myelitis, and aseptic meningitis. Easily obtainable biomarkers are needed to assist in early diagnosis and improve outcomes for NPSLE. A frequent end-result of major syndromes is neuronal or glial injury. Blood-based neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) have been utilized as markers for monitoring disease activity and/or severity in other neurodegenerative and neuroinflammatory diseases; however, they have not been evaluated in active major NPSLE.

Methods

This was a case-control study. We enrolled patients aged 12-60 years with active major NPSLE, SLE without act

SUBMITTER: Kammeyer R 

PROVIDER: S-EPMC11405133 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature