Integrative study of chicken lung transcriptome to understand the host immune response during Newcastle disease virus challenge.

ABSTRACT:

Introduction

Newcastle disease is one of the significant issues in the poultry industry, having catastrophic effects worldwide. The lung is one of the essential organs which harbours Bronchus-associated lymphoid tissue and plays a vital role in the immune response. Leghorn and Fayoumi breeds are known to have differences in resistance to Newcastle disease. Along with genes and long non-coding RNAs (lncRNAs) are also known to regulate various biological pathways through gene regulation.

Methods

This study analysed the lung transcriptome data and identified the role of genes and long non-coding RNAs in differential immune resistance. The computational pipeline, FHSpipe, as used in our previous studies on analysis of harderian gland and trachea transcriptome was used to identif

SUBMITTER: Vanamamalai VK 

PROVIDER: S-EPMC11405381 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature