Reward system neurodynamics during menstrual pain modulated by COMT Val158Met polymorphisms.

ABSTRACT:

Introduction

Primary dysmenorrhea (PDM), characterized by cyclic pain, may involve pain modulation within the reward system (RS). The Catechol-O-methyltransferase (COMT) Val158Met polymorphism, which significantly influences dopamine activity, is linked to the regulation of both acute and chronic pain. This study examines the differential neurodynamic modulation in the RS associated with COMT Val158Met polymorphisms during menstrual pain among PDM subjects.

Method

Ninety-one PDM subjects underwent resting-state fMRI during menstruation and were genotyped for COMT Val158Met polymorphisms. The amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) analyses were used to assess the RS response. Psychological evaluations included the M

SUBMITTER: Hsu PS 

PROVIDER: S-EPMC11405383 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature