Unraveling the role of hepatitis B virus DNA integration in B-cell lymphomagenesis.

ABSTRACT:

Background

Studies have shown that hepatitis B virus (HBV)-associated B-cell non-Hodgkin lymphoma (NHL) constitutes a unique subgroup with distinct clinical features. It still leaves open the question of whether the integration of HBV DNA into the B-cell genome is a causal mechanism in the development of lymphoma.

Methods

Using the hybridisation capture-based next generation sequencing and RNA sequencing, we characterised the HBV integration pattern in 45 HBV-associated B-cell NHL tumour tissues.

Results

A total of 354 HBV integration sites were identified in 13 (28.9%) samples, indicating the relatively low integration frequency in B-cell NHLs. High plasma HBV DNA loads were not associated with the existence of HBV integration. The insertion sites distributed randoml

SUBMITTER: Cheng CL 

PROVIDER: S-EPMC11405389 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature