Mixture and Non-mixture Cure Models for Health Technology Assessment: What You Need to Know.

ABSTRACT: There is increasing interest in the use of cure modelling to inform health technology assessment (HTA) due to the development of new treatments that appear to offer the potential for cure in some patients. However, cure models are often not included in evidence dossiers submitted to HTA agencies, and they are relatively rarely relied upon to inform decision-making. This is likely due to a lack of understanding of how cure models work, what they assume, and how reliable they are. In this tutorial we explain why and when cure models may be useful for HTA, describe the key characteristics of mixture and non-mixture cure models, and demonstrate their use in a range of scenarios, providing Stata code. We highlight key issues that must be taken into account by analysts when fitting these models

SUBMITTER: Latimer NR 

PROVIDER: S-EPMC11405446 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature