Neural stem cells derived from α-synuclein-knockdown iPS cells alleviate Parkinson's disease.

ABSTRACT: Stem cells have the potential to replace damaged or defective cells and assist in the development of treatments for neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. iPS cells derived from patient-specific somatic cells are not only ethically acceptable, but they also avoid complications relating to immune rejection. Currently, researchers are developing stem cell-based therapies for PD using induced pluripotent stem (iPS) cells. iPS cells can differentiate into cells from any of the three germ layers, including neural stem cells (NSCs). Transplantation of neural stem cells (NSCs) is an emerging therapy for treating neurological disorders by restoring neuronal function. Nevertheless, there are still challenges associated with the quality and source of

SUBMITTER: Wang CH 

PROVIDER: S-EPMC11405526 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature