Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways.

ABSTRACT:

Background

Neurocognitive dysfunction is observationally associated with the risk of psychiatric disorders. Blood metabolites, which are readily accessible, may become highly promising biomarkers for brain disorders. However, the causal role of blood metabolites in neurocognitive function, and the biological pathways underlying their association with psychiatric disorders remain unclear.

Methods

To explore their putative causalities, we conducted bidirectional two-sample Mendelian randomization (MR) using genetic variants associated with 317 human blood metabolites (n_max = 215,551), g-Factor (an integrated index of multiple neurocognitive tests with n_max = 332,050), and 10 different psychiatric disorders (n = 9,725 to 807,553) from the large-scale genom

SUBMITTER: Guo J 

PROVIDER: S-EPMC11405529 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature