Innate immunity gene Nod2 protects mice from orthotopic breast cancer.

ABSTRACT:

Background

Nod2 is involved in innate immune responses to bacteria, regulation of metabolism, and sensitivity to cancer. A Nod2 polymorphism is associated with breast cancer, but the role of Nod2 in the development and progression of breast cancer is unknown.

Methods

Here, we tested the hypothesis that Nod2 protects mice from breast cancer using the 4T1 orthotopic model of mammary tumorigenesis. WT and Nod2^-/- mice were injected with 4T1 mammary carcinoma cells and the development of tumors was monitored. A detailed analysis of the tumor transcriptome was performed and genes that were differentially expressed and pathways that were predicted to be altered between WT and Nod2^-/- mice were identified. The activation of key signaling molecules involved in

SUBMITTER: Gurses S 

PROVIDER: S-EPMC11405536 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature