BCORL1, POF1B, and USP9X copy number variation in women with idiopathic diminished ovarian reserve.

ABSTRACT:

Purpose

To analyze the copy number variation (CNV) in the X-linked genes BCORL1, POF1B, and USP9X in idiopathic diminished ovarian reserve (DOR).

Methods

This case-control study included 47 women, 26 with DOR and 21 in the control group. Age, weight, height, BMI, and FSH level were evaluated, as well as antral follicle count (AFC), oocyte retrieval after controlled ovarian stimulation, and metaphase II (MII) oocytes. The CNVs of BCORL1, USP9X, and POF1B genes were measured by quantitative real time PCR (qPCR) using two reference genes, the HPRT1 (X-linked) and MFN2 (autosomal). Protein-protein interaction network and functional enrichment analysis were performed using the STRING database.

Results

The mean age was 36.52 ± 4.75 in DOR women and 35.38 ± 4.14 in control.

SUBMITTER: Furtado CLM 

PROVIDER: S-EPMC11405560 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature