Combinatorial biosynthesis of novel aminoglycoside antibiotics via pathway engineering.

ABSTRACT: With the current spread of clinically relevant multidrug-resistant (MDR) pathogens, insufficient unearthing of new anti-infectives, and the high cost required for approval of new antimicrobial agents, a strong need for getting these agents via more economic and other alternative routes has emerged. With the discovery of the biosynthetic pathways of various antibiotics pointing out the role of each gene/protein in their antibiotic-producing strains, it became apparent that the biosynthetic gene clusters can be manipulated to produce modified antibiotics. This new approach is known as the combinatorial biosynthesis of new antibiotics which can be employed for obtaining novel derivatives of these valuable antibiotics using genetically modified antibiotic-producing strains (pathway engineering

SUBMITTER: Aboshanab KM 

PROVIDER: S-EPMC11405602 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature