Altered associations between white matter structure and psychopathology in previously institutionalized adolescents.

ABSTRACT: Previously institutionalized adolescents show increased risk for psychopathology, though placement into high-quality foster care can partially mitigate this risk. White matter (WM) structure is associated with early institutional rearing and psychopathology in youth. Here we investigate associations between WM structure and psychopathology in previously institutionalized youth. Adolescent psychopathology data were collected using the MacArthur Health and Behavior Questionnaire. Participants underwent diffusion MRI, and data were processed using fixel-based analyses. General linear models investigated interactions between institutionalization groups and psychopathology on fixel metrics. Supplementary analyses also examined the main effects of psychopathology and institutionalization group o

SUBMITTER: Kanel D 

PROVIDER: S-EPMC11405635 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature