Evaluation of ⁶⁸Ga-FAPI PET/CT and ¹⁸F-FDG PET/CT for the diagnosis of recurrent colorectal cancers.

ABSTRACT:

Objective

The present study aimed to compare the diagnostic value of gallium-68-labeled fibroblast activation protein inhibitor positron emission tomography/computed tomography (⁶⁸Ga-FAPI PET/CT) and fluorine-18-labeled fluorodeoxyglucose PET/CT (¹⁸F-FDG PET/CT) for detecting recurrent colorectal cancers (CRCs).

Materials and methods

Fifty-six patients (age: 18-80 years, 31 men and 25 women) with suspected recurrent CRC were enrolled and underwent ¹⁸F-FDG PET/CT and ⁶⁸Ga-FAPI PET/CT sequentially within 1 week. The maximum standard uptake value (SUVmax), tumor-to-background ratio (TBR), and diagnostic accuracy were estimated and compared between the two modalities by using Student's t-test. The Wilcoxon signed-rank test was u

SUBMITTER: Xi Y 

PROVIDER: S-EPMC11405641 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature