The cellular prion protein does not affect tau seeding and spreading of sarkosyl-insoluble fractions from Alzheimer's disease.

ABSTRACT: The cellular prion protein (PrP^C) plays many roles in the developing and adult brain. In addition, PrP^C binds to several amyloids in oligomeric and prefibrillar forms and may act as a putative receptor of abnormal misfolded protein species. The role of PrP^C in tau seeding and spreading is not known. In the present study, we have inoculated well-characterized sarkosyl-insoluble fractions of sporadic Alzheimer's disease (sAD) into the brain of adult wild-type mice (Prnp^+/+), Prnp^0/0 (ZH3 strain) mice, and mice over-expressing the secreted form of PrP^C lacking their GPI anchor (Tg44 strain). Phospho-tau (ptau) seeding and spreading involving neurons and oligodendrocytes were observed three and six months after inoculation. 3Rta

SUBMITTER: Sala-Jarque J 

PROVIDER: S-EPMC11405773 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature