Lipoprotein metabolism mediates hematopoietic stem cell responses under acute anemic conditions.

ABSTRACT: Hematopoietic stem cells (HSCs) react to various stress conditions. However, it is unclear whether and how HSCs respond to severe anemia. Here, we demonstrate that upon induction of acute anemia, HSCs rapidly proliferate and enhance their erythroid differentiation potential. In severe anemia, lipoprotein profiles largely change and the concentration of ApoE increases. In HSCs, transcription levels of lipid metabolism-related genes, such as very low-density lipoprotein receptor (Vldlr), are upregulated. Stimulation of HSCs with ApoE enhances their erythroid potential, whereas HSCs in Apoe knockout mice do not respond to anemia induction. Vldlr^highHSCs show higher erythroid potential, which is enhanced after acute anemia induction. Vldlr^highHSCs are epigenetically disti

SUBMITTER: Saito K 

PROVIDER: S-EPMC11405780 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature