Insulin-like Growth Factor-1 Levels Reflect Muscle and Bone Health and Determine Complications and Mortality in Decompensated Cirrhosis.

ABSTRACT:

Background

The growth hormone-insulin-like growth factor (GH-IGF-1) axis and its impairment with sarcopenia, frailty, bone health, complications, and prognosis are not well characterized in cirrhosis.

Methods

We investigated the adult decompensated cirrhosis out-patients at a tertiary care institute between 2021 and 2023 for serum GH and IGF-1 levels, and associated them with sarcopenia (CT-SMI in cm²/m²), liver frailty index (LFI), osteodystrophy (DEXA), clinical decompensations (overall, ascites, encephalopathy, infection, and bleed), and survival up to 180 days.

Results

One-hundred-seventy-two patients, 95% males, aged 46.5 years (median). _logIGF-1 levels were negatively associated with sarcopenia, osteodystrophy, LFI, CTP, and MELD

SUBMITTER: Kaur P 

PROVIDER: S-EPMC11405804 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature