Critical assessment of infants born to mothers with drug resistant tuberculosis.

ABSTRACT:

Background

There have been no detailed descriptions of infants born to mothers treated for drug resistant TB in pregnancy. Critical case history assessment is important to identify risks and guide clinical practice.

Methods

In a cohort of pregnant women with multidrug or rifampicin resistant (MDR/RR)-TB enrolled between 1 January 2013 and 31 December 2022, we followed mother-infant pairs until the infant was 12 months old. We performed critical case history assessments to explore potential mechanisms of Mycobacterium tuberculosis transmission to the infant, and to describe the clinical presentation and disease trajectories observed in infants diagnosed with TB.

Findings

Among 101 mother-infant pairs, 23 (23%) included infants diagnosed with TB disease; 16 were

SUBMITTER: Loveday M 

PROVIDER: S-EPMC11405821 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature