Association between alcohol consumption and incidence of dementia in current drinkers: linear and non-linear mendelian randomization analysis.

ABSTRACT:

Background

Previous conventional epidemiological studies found a J-shape relationship between alcohol consumption and dementia, but this result was subject to confounding biases and reverse causation. Therefore, we aimed to investigate the potential linear or non-linear causal association between alcohol consumption and the incident risk of dementia in current drinkers.

Methods

This study used data from the UK Biobank to investigate the relationship between alcohol consumption and dementia risk. 313,958 White British current drinkers, who were free of dementia during 2006-2010, were followed up until 2021. Alcohol consumption was self-reported and calculated according to the National Health Service guideline. The primary outcome was all-cause dementia identified through hosp

SUBMITTER: Zheng L 

PROVIDER: S-EPMC11405827 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature