Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients.

ABSTRACT:

Aims

Acute heart failure (AHF) is typified by inflammatory and oxidative stress responses, which are associated with unfavorable patient outcomes. Given the anti-inflammatory and antioxidant properties of high-density lipoprotein (HDL), this study sought to examine the relationship between impaired HDL function and mortality in AHF patients. The complex interplay between various HDL-related biomarkers and clinical outcomes remains poorly understood.

Methods

HDL subclass distribution was quantified by nuclear magnetic resonance spectroscopy. Lecithin-cholesterol acyltransferase (LCAT) activity, cholesterol ester transfer protein (CETP) activity, and paraoxonase (PON-1) activity were assessed using fluorometric assays. HDL-cholesterol efflux capacity (CEC) was assessed in a va

SUBMITTER: Pammer A 

PROVIDER: S-EPMC11406013 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature