Improving Cardiovascular Disease Primary Prevention Treatment Thresholds in a New England Health Care System.

ABSTRACT:

Background

Atherosclerotic cardiovascular disease (ASCVD) risk estimation based on the pooled cohort equation (PCE) overestimates in population-based cohorts. Whether it performs equally across disaggregated demographics in health care populations is less known.

Objectives

The purpose of the study was to recalibrate PCE and rederive prevention thresholds in a contemporary health care system and evaluate its performance across sociodemographics.

Methods

We retrospectively inspected electronic health records between 2010 to 2012 and 2020 to 2022 within Mass General Brigham health care in New England region. We compared performance of the original vs recalibrated PCE measured by calibration, discrimination, reclassification rate, and net benefit among 160,926 patients ag

SUBMITTER: Cho SMJ 

PROVIDER: S-EPMC11406032 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature