Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study.

ABSTRACT:

Objective

In a previous pilot study, we have shown that intraarticular gold micro-particles can reduce knee osteoarthritis (KOA) pain at two years follow-up. Proteomic changes in serum and synovial fluid within eight weeks were associated with multiple inflammatory and immunological processes. The relation between the different biomarkers and the outcome measures is not known. We hypothesized that improvement in pain and function were associated with specific groups of biomarkers. We present the integrative analyses between proteomic biomarkers and outcomes.

Design

A cohort of 30 patients, with moderate KOA, were included. Using the patients' synovial fluid as the carrier, 20 ​mg gold microparticles were injected intraarticularly. Clinical outcome measures at inclusion, 8 we

SUBMITTER: Rasmussen S 

PROVIDER: S-EPMC11406078 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature