Impact of ovalbumin allergy on oral and gut microbiome dynamics in 6-week-old BALB/c mice.

ABSTRACT:

Background

The gut microbiota is known to have a significant impact on the development of food allergy, and several recent studies have suggested that both oral microbiota, which first come into contact with allergenic foods, may have a profound influence on the development of food allergy.

Methods

In this study, we have established an ovalbumin-sensitive mice model by utilizing ovalbumin as a sensitizing agent. Subsequently, we performed a comprehensive analysis of the gut and oral microbiota in ovalbumin-sensitive mice and the control mice using full-length 16S rRNA sequencing analysis.

Results

Interestingly, both the gut and oral microbiota of ovalbumin-sensitized mice exhibited significant dysbiosis. The relative abundance of s__Lactobacillus_intestinalis i

SUBMITTER: Qiao C 

PROVIDER: S-EPMC11406088 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature