MDMA enhances positive affective responses to social feedback.

ABSTRACT:

Background

The prosocial compound ± 3,4-methylenedioxymethamphetamine (MDMA) is an amphetamine derivative that has shown promise as an adjunct to psychotherapy in the treatment of post-traumatic stress disorder. MDMA increases positive responses to social images, and it has been suggested that the ability of MDMA to positively bias social perception may underlie its therapeutic efficacy as a psychotherapy adjunct. However, the effect of the compound on affective responses to positive or negative social feedback has not been tested.

Aims

In this study, we aimed to test the effects of MDMA compared to placebo and the prototypical stimulant, methamphetamine (MA), on responses to positive and negative social feedback.

Methods

This was a double-blind, placebo-controlled, c

SUBMITTER: Bershad AK 

PROVIDER: S-EPMC11406195 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature