Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels.

ABSTRACT: In the brain, a microvascular sensory web coordinates oxygen delivery to regions of neuronal activity. This involves a dense network of capillaries that send conductive signals upstream to feeding arterioles to promote vasodilation and blood flow. Although this process is critical to the metabolic supply of healthy brain tissue, it may also be a point of vulnerability in disease. Deterioration of capillary networks is a feature of many neurological disorders and injuries and how this web is engaged during vascular damage remains unknown. We performed in vivo two-photon microscopy on young adult mural cell reporter mice and induced focal capillary injuries using precise two-photon laser irradiation of single capillaries. We found that ~59% of the injuries resulted in regression of the capil

SUBMITTER: Bonney SK 

PROVIDER: S-EPMC11406265 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature