Single-molecule force spectroscopy reveals intra- and intermolecular interactions of <i>Caenorhabditis elegans</i> HMP-1 during mechanotransduction.

ABSTRACT: The Caenorhabditis elegans HMP-2/HMP-1 complex, akin to the mammalian [Formula: see text]-catenin-[Formula: see text]-catenin complex, serves as a critical mechanosensor at cell-cell adherens junctions, transducing tension between HMR-1 (also known as cadherin in mammals) and the actin cytoskeleton. Essential for embryonic development and tissue integrity in C. elegans, this complex experiences tension from both internal actomyosin contractility and external mechanical microenvironmental perturbations. While offering a valuable evolutionary comparison to its mammalian counterpart, the impact of tension on the mechanical stability of HMP-1 and HMP-2/HMP-1 interactions remains unexplored. In this study, we directly quantified the mechanical stability of full-length HMP-1 and it

SUBMITTER: Le S 

PROVIDER: S-EPMC11406289 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature