Regulation of intercellular viscosity by E-cadherin-dependent phosphorylation of EGFR in collective cell migration.

ABSTRACT: Collective cell migration is crucial in various physiological processes, including wound healing, morphogenesis, and cancer metastasis. Adherens Junctions (AJs) play a pivotal role in regulating cell cohesion and migration dynamics during tissue remodeling. While the role and origin of the junctional mechanical tension at AJs have been extensively studied, the influence of the actin cortex structure and dynamics on junction plasticity remains incompletely understood. Moreover, the mechanisms underlying stress dissipation at junctions are not well elucidated. Here, we found that the ligand-independent phosphorylation of epithelial growth factor receptor (EGFR) downstream of de novo E-cadherin adhesion orchestrates a feedback loop, governing intercellular viscosity via the Rac pathway regula

SUBMITTER: Fu C 

PROVIDER: S-EPMC11406304 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature