Several orphan solute carriers functionally identified as organic cation transporters: Substrates specificity compared with known cation transporters.

ABSTRACT: Organic cations comprise a significant part of medically relevant drugs and endogenous substances. Such substances need organic cation transporters for efficient transfer via cell membranes. However, the membrane transporters of most natural or synthetic organic cations are still unknown. To identify these transporters, genes of 10 known OCTs and 18 orphan solute carriers (SLC) were overexpressed in HEK293 cells and characterized concerning their transport activities with a broad spectrum of low molecular weight substances emphasizing organic cations. Several SLC35 transporters and SLC38A10 significantly enhanced the transport of numerous relatively hydrophobic organic cations. Significant organic cation transport activities have been found in gene families classified as transporters of ot

SUBMITTER: Redeker KM 

PROVIDER: S-EPMC11406361 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature