West African Genetic Ancestry, Neighborhood Deprivation, and Prostate Cancer.

ABSTRACT:

Importance

Racial disparities in prostate cancer are likely the result of complex relationships between both socioeconomic and environmental factors captured by the neighborhood environment and genetic factors, including West African genetic ancestry. However, few studies have examined the combined role of neighborhood environment and genetic ancestry in developing lethal prostate cancer.

Objective

To examine the interactions between West African genetic ancestry and neighborhood deprivation in modifying prostate cancer risk and mortality.

Design, setting, and participants

This case-control study was conducted in the Greater Baltimore area. Participants included men of African and European descent (617 cases with prostate cancer, 852 controls without prostate cancer)

SUBMITTER: Pichardo CM 

PROVIDER: S-EPMC11406387 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature