Synergism of d-limonene and temozolomide on migratory and apoptotic behaviors of human glioblastoma cell lines.

ABSTRACT:

Introduction

Glioblastoma (GBM), which is a heterogeneous and aggressive type of brain tumor, is known for its poor survival outcomes. The treatment of GBM remains challenging primarily due to the drug resistance to the current standard therapeutic option, temozolomide (TMZ). Researchers are currently focusing on developing an appropriate alternative combinatorial therapeutic to enhance treatment outcomes. D-limonene (DL) is a monoterpene derived from citrus fruit. This study aims to assess the impact of combining DL with TMZ and explore its potential mechanism of action in U87MG and LN229 GBM cells.

Methods

The effects of the combined treatment of DL and TMZ were assessed on various cellular aspects, including cell viability, anchorage-independent cell growth, and DNA damag

SUBMITTER: Gautam M 

PROVIDER: S-EPMC11406426 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature