High rate of recurrent venous thromboembolism in children and adolescents with unprovoked venous thromboembolism.

ABSTRACT:

Background

Unprovoked venous thromboembolism (VTE) is rare in pediatrics. Current recommendations for anticoagulation duration after unprovoked VTE differ for pediatric and adult populations.

Objectives

This single-center, retrospective cohort study aimed to determine the incidence rate of recurrent VTE in children and adolescents with unprovoked VTE, evaluate the potential risk factors for recurrence, and describe the anticoagulation regimens and bleeding in this population.

Methods

Children with an index, unprovoked VTE at the age of 1 to <21 years between 2003 and 2021 were included. The time to recurrent VTE and anticoagulation duration were summarized using Kaplan-Meier estimators. Clinical covariates were assessed for association with recurrence using stratified

SUBMITTER: Whitworth H 

PROVIDER: S-EPMC11406432 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature