Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies.

ABSTRACT: Major depression (MD) is a serious psychiatric illness afflicting nearly 5% of the world's population. A large correlational literature suggests that loneliness is a prospective risk factor for MD; correlational assocations of this nature may be confounded for a variety of reasons. This report uses Mendelian Randomization (MR) to examine potentially causal associations between loneliness and MD. We report on analyses using summary statistics from three large genome wide association studies (GWAS). MR analyses were conducted using three independent sources of GWAS summary statistics. In the first set of analyses, we used available summary statistics from an extant GWAS of loneliness to predict MD risk. We used two sources of outcome data: the Psychiatric Genomics Consortium (PGC) meta-analy

SUBMITTER: Sbarra DA 

PROVIDER: S-EPMC11406447 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature