Reaction Risk to Direct Penicillin Challenges: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

While direct penicillin challenges might support the expansion of penicillin allergy delabeling efforts, the perceived risk of reactions remains a key barrier.

Objective

To evaluate the frequency of reactions to direct penicillin challenges in individuals with penicillin allergy labels and to identify factors associated with such reactions.

Data sources

Three electronic databases were searched (MEDLINE, Web of Science, and Scopus) from inception to July 19, 2023, for primary studies assessing patients undergoing direct penicillin challenges. Articles were included regardless of publication year, language, status, or definition of allergy risk.

Study selection

Two reviewers independently selected original studies reporting the frequency of immunologic

SUBMITTER: Blumenthal KG 

PROVIDER: S-EPMC11406457 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature