The causal relationship between immune cells and diabetic retinopathy: a Mendelian randomization study.

ABSTRACT:

Purpose

This article explored the causal relationship between immune cells and diabetic retinopathy (DR) using single nucleotide polymorphisms (SNPs) as an instrumental variable and Mendelian randomization (MR).

Methods

Statistical data were collected from a publicly available genome-wide association study (GWAS), and SNPs that were significantly associated with immune cells were used as instrumental variables (IVs). Inverse variance weighted (IVW) and MR-Egger regression were used for MR analysis. A sensitivity analysis was used to test the heterogeneity, horizontal pleiotropy, and stability of the results.

Results

We investigated the causal relationship between 731 immune cells and DR risk. All the GWAS data were obtained from European populations and from men and w

SUBMITTER: Ye Y 

PROVIDER: S-EPMC11406504 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature