Identification of ribosome biogenesis genes and subgroups in ischaemic stroke.

ABSTRACT:

Background

Ischaemic stroke is a leading cause of death and severe disability worldwide. Given the importance of protein synthesis in the inflammatory response and neuronal repair and regeneration after stroke, and that proteins are acquired by ribosomal translation of mRNA, it has been theorised that ribosome biogenesis may have an impact on promoting and facilitating recovery after stroke. However, the relationship between stroke and ribosome biogenesis has not been investigated.

Methods

In the present study, a ribosome biogenesis gene signature (RSG) was developed using Cox and least absolute shrinkage and selection operator (LASSO) analysis. We classified ischaemic stroke patients into high-risk and low-risk groups using the obtained relevant genes, and further elucidate

SUBMITTER: Wang X 

PROVIDER: S-EPMC11406505 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature