Optical Enantiodifferentiation of Chiral Nitriles.

ABSTRACT: Chiroptical sensing of nitriles is achieved with excellent functional group tolerance by hydrozirconation and subsequent transmetalation of the corresponding iminate to a chromophoric palladium complex. A one-pot workflow that uses the Schwartz reagent and [(η³-1-tert-butylindenyl)(μ-Cl)Pd]₂ as sensor generates a palladium complex displaying red-shifted CD inductions and characteristic UV changes. These chiroptical responses are accurately correlated to the enantiomeric ratio and total concentration of the original nitrile.

SUBMITTER: Formen JSSK 

PROVIDER: S-EPMC11406584 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature