The pleural gradient does not reflect the superimposed pressure in patients with class III obesity.

ABSTRACT:

Background

The superimposed pressure is the primary determinant of the pleural pressure gradient. Obesity is associated with elevated end-expiratory esophageal pressure, regardless of lung disease severity, and the superimposed pressure might not be the only determinant of the pleural pressure gradient. The study aims to measure partitioned respiratory mechanics and superimposed pressure in a cohort of patients admitted to the ICU with and without class III obesity (BMI ≥ 40 kg/m²), and to quantify the amount of thoracic adipose tissue and muscle through advanced imaging techniques.

Methods

This is a single-center observational study including ICU-admitted patients with acute respiratory failure who underwent a chest computed tomography scan within three days befo

SUBMITTER: Spina S 

PROVIDER: S-EPMC11406718 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature