Lipid metabolites and sarcopenia-related traits: a Mendelian randomization study.

ABSTRACT:

Objective

To explore the influence of lipid metabolism on the risk of sarcopenia.

Methods

Two-sample Mendelian randomization (MR) analysis was used to determine causality. A total of 179 lipid metabolism data points were used for exposure, and the data were obtained from a plasma lipid metabolite study of 7174 participants. The total muscle mass and total muscle strength, as well as the muscle strength and muscle mass of different sex groups, were selected as the relevant traits of sarcopenia. Data for outcomes were obtained from the UK Biobank, and sample sizes ranged from 135 468 to 450 243. Inverse-variance weighted (IVW), as the main method for evaluating the causal relationship between lipid metabolites and sarcopenia, uses the false discovery rate (FDR) for multiple co

SUBMITTER: Liu J 

PROVIDER: S-EPMC11406728 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature